Hi Francesco
If you want to use Act costing/Material ledger concept only valuation inventory in multiple currency/valuation you should activate Material Ledger only. In that case you can choose price determination 2 in combination with S/V both as you like.
But if you want actual costing to calculate PUP then you must activate Actual costing in addition to Material Ledger and in that case only combination is S/3.
I think you can decide now